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White Paper

Thyroid RFA: A 10-Year Clinical Follow-Up

Exploring a Decade of Lasting Relief After Radiofrequency Ablation
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Thyroid RFA: 10-Year Clinical Follow-Up White Paper

A Non-Surgical Approach to Thyroid Nodule Reduction

Radiofrequency ablation (RFA) is fast becoming a safe, proven alternative to thyroidectomy surgery. It’s a non-surgical outpatient technique that has been used to treat benign and malignant thyroid nodules for over 20 years.1-4

This white paper examines the efficacy of RFA at reducing nodule size, with post-treatment evaluations ranging from 6 months to 10 years.

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Featured RFA Study Highlights

RFA has been shown to reduce the size of thyroid nodules durably in multiple clinical studies.

Park et al.5 studied the efficacy of RFA of benign nodules with 421 patients. Average nodule size was reduced by:

  • 63% after 6 months
  • 81% after 2 years
  • 90% after 5 years
  • 94% after 10 years

Jeong et al.6 evaluated RFA treatment of low-risk papillary microcarcinoma in 65 patients. The average nodule volume reduction reported was:

  • 40.8% after 6 months
  • 74.6% after 1 year
  • 100% after 2-10 years
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References
  1. Dupuy DE, Monchik JM, Decrea C, Pisharodi L. Radiofrequency ablation of regional recurrence from well-differentiated thyroid malignancy. Surgery. 2001 Dec;130(6):971-7. doi: 10.1067/msy.2001.118708. Erratum in: Surgery. 2022 Apr;171(4):1138. doi: 10.1016/j.surg.2021.12.008.
  2. Kim YS, Rhim H, Tae K, Park DW, Kim ST. Radiofrequency ablation of benign cold thyroid nodules: initial clinical experience. Thyroid. 2006 Apr;16(4):361-7. doi: 10.1089/thy.2006.16.361
  3. Baek JH, Jeong HJ, Kim YS, Kwak MS, Lee D. Radiofrequency ablation for an autonomously functioning thyroid nodule. Thyroid. 2008 Jun;18(6):675-6. doi: 10.1089/thy.2007.0274
  4. Tufano RP, Pace-Asciak P, Russell JO, Suárez C, Randolph GW, López F, Shaha AR, Mäkitie A, Rodrigo JP, Kowalski LP, Zafereo M, Angelos P, Ferlito A. Update of Radiofrequency Ablation for Treating Benign and Malignant Thyroid
  5. Park SI, Baek JH, Lee DH, Chung SR, Song DE, Kim WG, Kim TY, Sung TY, Chung KW, Lee JH. Radiofrequency Ablation for the Treatment of Benign Thyroid Nodules: 10-Year Experience. Thyroid. 2024 Aug;34(8):990-998. doi: 10.1089/thy.2024.0082.
  6. Jeong SY, Baek SM, Shin S, Son JM, Kim H, Baek JH. Radiofrequency Ablation of Low-Risk Papillary Thyroid Microcarcinoma: A Retrospective Cohort Study Including Patients with More than 10 Years of Follow-up. Thyroid. 2025 Feb;35(2):143-152. doi: 10.1089/thy.2024.0535.
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